To kick off their 2022 NFL regular season, Brian Daboll’s New York Giants will take a trip to Tennessee to take on Derrick Henry and the Titans.
The Titans and head coach Mike Vrabel will look to run it back after securing the No. 1 seed in the AFC playoffs last season behind Henry and veteran quarterback Ryan Tannehill. Meanwhile, Daboll arrives in New York to find a team seeking its identity. Which team is more likely to win its division in 2022?
Here’s a look at the betting details and USA TODAY’s NFL staff picks for the Giants vs. Titans game:
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While I think Tennessee may slide this season, the Giants simply have too many holes to compete with the Titans. And since Derrick Henry is healthy and the most difficult running back in the NFL to bring down, I’m expecting Tennessee to control the ball throughout the game.
Derrick Henry is back, Ryan Tannehill is fighting for his job every week, and the Titans will be poised to get back to the playoffs after an early exit last season. The Giants’ rebuild is underway with new coach Brian Daboll, but it won’t start with a Week 1 win.
The return of Daniel Jones, a new coach and a preseason injury to New York’s top pick shouldn’t inspire confidence. So why are the returning AFC top-seeded Titans favored by less than a touchdown? 
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