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By Marla Sommer
Congratulations to Associate Professor Connie Wong who has been awarded the Heart Foundation Vanguard grant of $150,000.
“We are very grateful for the funding of this exciting project. This is a fundamental proof-of-concept project prior to testing our novel therapeutic strategy in other stroke models, and with larger animals and even non-human primates, before progressing to potential clinical trials,” said A/Prof Wong.
The current therapeutic strategy for patients with stroke, or people at high risk of cardiovascular diseases, relies heavily on inhibiting the activation of platelets to prevent future coagulation events. However, this approach is coupled with the potential side effects of bleeding complications which have been suggested to contribute to poor patient compliance. This project will test an innovative concept where platelet-microglial interplay after stroke can be specifically targeted with pH-responsive nanoparticles that are designed to direct their delivery into the highly acidic inflammatory ischaemic brain tissue.
The project sets out to prove that the stimulus-responsive nature of this nanomedicine therapeutic strategy, in this case, stroke-induced neuroinflammation, will be immensely powerful to facilitate specific drug delivery to avoid non-specific side effects.
About Monash University
Monash University is Australia’s largest university with more than 80,000 students. In the 60 years since its foundation, it has developed a reputation for world-leading high-impact research, quality teaching, and inspiring innovation.
With four campuses in Australia and a presence in Malaysia, China, India, Indonesia and Italy, it is one of the most internationalised Australian universities.
As a leading international medical research university with the largest medical faculty in Australia and integration with leading Australian teaching hospitals, we consistently rank in the top 50 universities worldwide for clinical, pre-clinical and health sciences.
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Last updated: Oct 2022

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