PHILADELPHIA – Katrín Björk Guðjónsdóttir had her first stroke at 21, followed by a blood clot. Several months later, she had a second massive stroke. There was little doubt about what the rest of her short life would look like.
Her tight-knit Icelandic family harbors a fatal genetic fluke. It causes a protein called beta-amyloid to build up and form clumps in their cells, triggering repeated strokes. Across generations of her extended family, people with this condition, called hereditary intracerebral hemorrhage, developed dementia in their 30s, 40s and 50s and died prematurely.
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